Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer.
Puran ZhangYun GuHanji FangYifan CaoJieti WangHao LiuHeng ZhangHe LiHongyong HeRuochen LiChao LinJiejie XuPublished in: Journal for immunotherapy of cancer (2022)
IL-1R1 served as an independent prognosticator and predictive biomarker for ACT and ICB in GC. Furthermore, IL-1R1 antagonists could be a novel agent alone or combined with current therapeutic strategies in GC.