Copper-Catalyzed Decarboxylation Cross-Coupling Cascade Reaction for Synthesis of Fused Dihydro-benzoxazinones.
Weidong JiangZhuo-Huan LiTuan-Jie LiJian-Quan LiuXiang-Shan WangPublished in: The Journal of organic chemistry (2024)
A protocol for a tandem copper-catalyzed intermolecular decarboxylation cross-coupling cascade between o -bromobenzoic acids and proline or piperic acid has been disclosed. The developed protocol allows access to a variety of synthetically useful fused benzoxazinones scaffolds with high efficiency and good functional group compatibility. A mechanistically sequential approach for the decarboxylation and dehydration coupling process was presented.