Isotope Exchange-Based 18 F-Labeling Methods.
Tao WangShengji LvZhaobiao MouZhenru ZhangTaotao DongZijing LiPublished in: Bioconjugate chemistry (2023)
18 F-Labeling methods for the preparation of 18 F-labeled molecular probes can be classified into electrophilic fluorination, nucleophilic fluorination, metal-F coordination, and 18 F/ 19 F isotope exchange. Isotope exchange-based 18 F-labeling methods demonstrate mild conditions featuring water resistance and facile high-performance liquid chromatography-free purification in direct 18 F-labeling of substrates. This paper systematically reviews isotope exchange-based 18 F-labeling methods sorted by the adjacent atom bonding with F, i.e., carbon and noncarbon atoms (Si, B, P, S, Ga, Fe, etc.). The respective isotope exchange mechanism, radiolabeling condition, radiochemical yield, molar activity, and stability of the 18 F-product are mainly discussed for each isotope exchange-based 18 F-labeling method as well as the cutting-edge application of the corresponding 18 F-labeled molecular probes.
Keyphrases
- gas chromatography
- high performance liquid chromatography
- tandem mass spectrometry
- single molecule
- small molecule
- mass spectrometry
- randomized controlled trial
- molecular dynamics
- fluorescence imaging
- pet ct
- quantum dots
- solid phase extraction
- ms ms
- computed tomography
- molecularly imprinted
- ionic liquid
- reduced graphene oxide
- fluorescent probe