Retinoid X Receptor Antagonists.

Published in: International journal of molecular sciences (2018)

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

Keyphrases

type diabetes
cardiovascular disease
machine learning
deep learning
genome wide
gene expression
glycemic control
dna methylation
adipose tissue
combination therapy
weight loss
binding protein
drug induced