Pravastatin-induced changes in expression of long non-coding and coding RNAs in endothelial cells.

Shweta SinghHien C NguyenMehroz EhsanDavid C R MichelsPriyanka SinghMohammad QaduraKrishna K Singh

Published in: Physiological reports (2021)

This is the first lncRNA and mRNA expression profiling of pravastatin-mediated changes in human endothelial cells. Our results reveal potential novel targets and mechanisms for pravastatin-mediated vascular protection in atherosclerosis.

Keyphrases

endothelial cells
high glucose
genome wide
poor prognosis
vascular endothelial growth factor
binding protein
cardiovascular disease
long non coding rna
single cell
dna methylation
type diabetes
long noncoding rna
induced pluripotent stem cells
risk assessment