Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity-induced coronary microvascular disease.
Soham A ShahJohn T EcholsChang-Yu SunMatthew J WolfFrederick H EpsteinPublished in: Magnetic resonance in medicine (2022)
Rate 3 accelerated FAC MRI enabled accurate quantification of EAT FAC in mice. EPL treatment shifted the EAT FAC toward increased unsaturation and was associated with improvement of coronary microvascular function.
Keyphrases
- adipose tissue
- mouse model
- coronary artery disease
- coronary artery
- magnetic resonance imaging
- fatty acid
- insulin resistance
- contrast enhanced
- high fat diet induced
- type diabetes
- heart failure
- weight loss
- high resolution
- combination therapy
- computed tomography
- physical activity
- magnetic resonance
- skeletal muscle
- body mass index
- replacement therapy
- weight gain
- diabetic rats
- atrial fibrillation