Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review.
Sayed Asmat Ali ShahNajeeb AkhterBibi Nazia AucklooIshrat KhanYanbin LuKuiwu WangBin WuYue-Wei GuoPublished in: Marine drugs (2017)
Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive and anti-inflammatory capacities. Moreover, various structural classes, as well as their technological uses will also be discussed.
Keyphrases
- anti inflammatory
- endothelial cells
- papillary thyroid
- mycobacterium tuberculosis
- small molecule
- candida albicans
- ms ms
- squamous cell
- emergency department
- squamous cell carcinoma
- pulmonary tuberculosis
- locally advanced
- randomized controlled trial
- hiv aids
- human health
- induced pluripotent stem cells
- risk assessment
- drug induced
- human immunodeficiency virus
- silver nanoparticles
- single cell
- chemotherapy induced