Exosomal miR-103a-3p from Crohn's creeping fat-derived ASCs contributes to intestinal fibrosis by targeting TGFBR3 and activating fibroblasts.
Wenwei QianYihan XuWeiwei WenLiang-Yu HuangZhen GuoWeiming ZhuYi LiPublished in: Journal of Crohn's & colitis (2023)
Our findings showed that exosomal miR-103a-3p from CF-ASCs promotes intestinal fibrosis by activating fibroblasts via TGFBR3 targeting, suggesting that CF-ASCs are potential therapeutic targets for intestinal fibrosis in CD.