Efficacy and safety of adjunctive oral therapy in Parkinson's disease with motor complications: a systematic review and network meta-analysis.

Vibuthi SisodiaLars DubbeldRob M A De BieGonçalo Silva DuarteJoão CostaJoke M Dijk

Published in: BMJ neurology open (2024)

COMT-Is, DRAs and MAOB-Is effectively reduce motor complications and increase incidence of dyskinesia. In the network meta-analysis, adjunctive use of DRAs appeared most effective.

Keyphrases

risk factors
systematic review
meta analyses
randomized controlled trial
bone marrow
mesenchymal stem cells
cell therapy
smoking cessation
network analysis