Quantitative MRI reveals heterogeneous impacts of treatment on diseased bone marrow in a mouse model of myelofibrosis.
Tanner H RobisonWinston LeeKathryn E LukerKristen PettitMoshe TalpazThomas L ChenevertBrian D RossGary D LukerPublished in: Magnetic resonance in medicine (2024)
Quantitative MRI revealed modest, heterogeneous improvements in bone marrow disease when treating mice with established myelofibrosis. These results emphasize the value of bone marrow MRI to assess treatment in preclinical models and the potential to advance clinical trials for patients.
Keyphrases
- bone marrow
- mesenchymal stem cells
- magnetic resonance imaging
- clinical trial
- contrast enhanced
- mouse model
- end stage renal disease
- high resolution
- diffusion weighted imaging
- chronic kidney disease
- ejection fraction
- newly diagnosed
- computed tomography
- stem cells
- prognostic factors
- randomized controlled trial
- mass spectrometry
- adipose tissue
- patient reported outcomes
- replacement therapy
- wild type