2,5-diketopiperazines mitigate the amount of advanced glycation end products accumulated with age in human dermal fibroblasts.

Our work shows for the first time that DKPs decrease the amount of carboxymethyl-lysine AGE in elderly human dermal fibroblasts grown in vitro. Therefore, diketopiperazines can be considered as compounds of interest for dermatological and cosmetic applications with an anti-ageing aim.