The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing.
Moeko TsutsuuraHiromu MoriyamaNana KojimaYuki MizukamiSho TashiroSumika OsaYuki EnokiKazuaki TaguchiKazutaka OdaSatoshi FujiiYoshiko TakahashiYukihiro HamadaToshimi KimuraYoshio TakesueKazuaki MatsumotoPublished in: BMC infectious diseases (2021)
We identified VCM trough concentrations and AUC values that correlated with effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed potential for decreasing nephrotoxicity.