Regioselective Synthesis of 3-Trifluoromethylpyrroles by [3 + 2] Cycloaddition of N -Acyl α-Amino Acids and 2-Bromo-3,3,3-trifluoropropene.

A mild and concise method for the synthesis of 3-trifluoromethylpyrroles via base-mediated [3 + 2] cycloaddition of N -acyl α-amino acids and 2-bromo-3,3,3-trifluoropropene is described. N -Acyl α-amino acids serve as 1,3-dipole precursors without additional activating agents directly. A high level of regioselectivity was observed, regardless of the electronic nature and size of the substituents on 1,3-dipoles.