Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

Debabrata Maity Yujeong Oh Lothar Gremer Wolfgang Hoyer Mazin MagzoubAndrew D Hamilton

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)

Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
oxidative stress
deep learning
endoplasmic reticulum stress
single molecule
cell death
cell proliferation
signaling pathway
bone marrow