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Metabolomic Profiling of Cholesterol Efflux Capacity in a Multiethnic Population: Insights From MESA.

Wynn G HunterAlexander G SmithRui C PintoSuzanne SaldanhaAnamika GangwarMandana PahlavaniSneha DeodharJohn T WilkinsAmbarish PandeyDavid HerringtonPhilip GreenlandJoanna TzoulakiAnand Rohatgi
Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)
We identified independent associations among CEC, the largest-sized particle subclasses of VLDL and HDL, and their constituent apolipoproteins and lipids. A large proportion of variation in CEC remained unexplained by metabolites and traditional clinical risk factors, supporting further investigation into genomic, proteomic, and phospholipidomic determinants of CEC.
Keyphrases
  • risk factors
  • ms ms
  • single cell
  • low density lipoprotein
  • fatty acid