Metabolomic Profiling of Cholesterol Efflux Capacity in a Multiethnic Population: Insights From MESA.
Wynn G HunterAlexander G SmithRui C PintoSuzanne SaldanhaAnamika GangwarMandana PahlavaniSneha DeodharJohn T WilkinsAmbarish PandeyDavid HerringtonPhilip GreenlandJoanna TzoulakiAnand RohatgiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
We identified independent associations among CEC, the largest-sized particle subclasses of VLDL and HDL, and their constituent apolipoproteins and lipids. A large proportion of variation in CEC remained unexplained by metabolites and traditional clinical risk factors, supporting further investigation into genomic, proteomic, and phospholipidomic determinants of CEC.