Precision therapy with quinidine of KCNT1-related epileptic disorders: A systematic review.

Da XuShuang ChenJun YangXiufeng WangZhi FangMan Li

Published in: British journal of clinical pharmacology (2022)

Therapeutic effects of quinidine on KCNT1-related epilepsies remained indefinite as contradictory results were detected in similar patients. Age, seizure types, genotypes of KCNT1 mutations and brain MRI did not influence the therapeutic effects of quinidine. Insensitivity to quinidine by a certain Kcnt1 genotype in molecular tests is predictive of its inefficacy in human populations of the respective mutation.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
magnetic resonance imaging
peritoneal dialysis
computed tomography
patient reported outcomes
diffusion weighted imaging
brain injury
cerebral ischemia
blood brain barrier
pluripotent stem cells
subarachnoid hemorrhage