Analysis of Changes in Plasma Cytokine Levels in Response to IL12 Therapy in Three Clinical Trials.

IL12 activates immune cells and is used to treat cancer. The profile of circulating cytokines was measured in an exploratory fashion in patients with cancer that received IL12 in combination with mAbs. This correlative pilot study could serve as the basis for additional studies of IL12 effects on the production of immune cytokines.