Systematic integration of molecular and clinical approaches in HCV-induced hepatocellular carcinoma.
Ciniso Sylvester ShabanguWen-Hsiu SuChia-Yang LiMing-Lung YuChia-Yen DaiJee-Fu HuangWan-Long ChuangShu-Chi WangPublished in: Journal of translational medicine (2024)
Persistent HCV infection induced the expression of miRNAs that act as tumor suppressors by inhibiting oncogenes in HCC. RCN1 was suppressed while miRNAs were upregulated, demonstrating an inverse relationship. Therefore, hsa-miR-215-5p, hsa-miR-10b-5p, hsa-let-7a-5p and their target RCN1 may be ideal biomarkers for monitoring HCV-HCC progression.