Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
Nouf AljobailyKelsey KrutsingerMichael J VierecklRaznin JolyBridger MenloveBrexton ConeAilaina SuppesYuyan HanPublished in: Nutrients (2022)
Collectively, the low dose of CBG alleviated hepatic fibrosis and inflammation in MCD-induced NASH, however, the high dose of CBG treatment showed enhanced liver damage when compared to MCD only group. These results will provide pre-clinical data to guide future intervention studies in humans addressing the potential uses of CBG for inflammatory liver pathologies, as well as open the door for further investigation into systemic inflammatory pathologies.
Keyphrases
- low dose
- oxidative stress
- high dose
- diabetic rats
- stem cell transplantation
- randomized controlled trial
- minimally invasive
- high glucose
- electronic health record
- drug induced
- big data
- liver fibrosis
- machine learning
- risk assessment
- combination therapy
- amino acid
- replacement therapy
- climate change
- data analysis
- deep learning