Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression.
Guangchun HanQing DengMario L Marques-PiubelliEnyu DaiMinghao DangMan Chun John MaXubin LiHaopeng YangJared HendersonOlga Mikhaylovna PlotnikovaMark MeersonSergey IsaevNikita KotlovKrystle J NomieAlexander V BagaevEdwin Roger Parra CuentesLuisa Maren Solis SotoSimrit ParmarFredrick B HagemeisterSairah A AhmedSwaminathan P IyerFelipe SamaniegoRaphael E SteinerLuis FayadJee Hun LeeNathan Hale FowlerChristopher R FlowersPaolo StratiJason R WestinSattva S NeelapuLoretta J NastoupilFrancisco VegaLinghua WangMichael R GreenPublished in: Blood cancer discovery (2022)
We have characterized the FL-infiltrating T cells, identified cytotoxic CD4 T cells as an important component that is associated with tumor cell-intrinsic characteristics, and identified sets of targetable immune checkpoints on T cells that differed from FLs with normal versus low MHC expression. See related commentary by Melnick, p. 374. This article is highlighted in the In This Issue feature, p. 369.