Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review.
Lisanne K A NeijenhuisLysanne D A N de MuynckOkker D BijlstraPeter J K KuppenDenise E HillingFrank J BormDanielle CohenJ Sven D MieogWillem H SteupJerry BraunJacobus BurggraafAlexander L VahrmeijerMerlijn HuttemanPublished in: Life (Basel, Switzerland) (2022)
Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, since small and deeply located pulmonary nodules can be invisible under white light. Due to the increasing use of minimally invasive surgical techniques, tactile information is often reduced. Therefore, several intraoperative imaging techniques have been tested to localize pulmonary nodules, of which near-infrared (NIR) fluorescence is an emerging modality. In this systematic review, the available literature on fluorescence imaging of lung cancers is presented, which shows that NIR fluorescence-guided lung surgery has the potential to identify the tumor during surgery, detect additional lesions and prevent tumor-positive resection margins.
Keyphrases
- fluorescence imaging
- minimally invasive
- systematic review
- photodynamic therapy
- small cell lung cancer
- single molecule
- high resolution
- coronary artery bypass
- pulmonary hypertension
- advanced non small cell lung cancer
- patients undergoing
- robot assisted
- squamous cell carcinoma
- atrial fibrillation
- randomized controlled trial
- cancer therapy
- newly diagnosed
- health information
- human health
- epidermal growth factor receptor
- acute coronary syndrome
- squamous cell
- brain metastases
- loop mediated isothermal amplification
- childhood cancer