Endovascular treatment for ischemic stroke patients with and without atrial fibrillation, and the effects of adjunctive pharmacotherapy: a narrative review.
Muath AlobaidaGregory Y H LipDeirdre A LaneDimitrios SagrisAzmil H Abdul-RahimStephanie L HarrisonPublished in: Expert opinion on pharmacotherapy (2023)
There is little evidence from randomized controlled trials on the effect of AF on stroke outcomes following EVT and the safety and efficacy of AF treatment in the peri-EVT such as tirofiban or Intravenous thrombolysis with Non-vitamin K Antagonist Oral Anticoagulant. The available evidence from observational studies on AF and EVT outcomes is inconsistent, but factors such as procedural EVT devices, the center volume, clinician experience, stroke recognition, and inclusion criteria of studies have all been associated with poorer clinical outcomes. Enhancing the clinical network among prehospital and hospitals will facilitate direct transfer to EVT centers, reducing stroke onset to EVT time and optimizing stroke outcomes.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- direct oral anticoagulants
- heart failure
- endovascular treatment
- percutaneous coronary intervention
- randomized controlled trial
- healthcare
- cardiac arrest
- pulmonary embolism
- low dose
- adipose tissue
- systematic review
- venous thromboembolism
- brain injury
- type diabetes
- insulin resistance
- weight loss
- blood brain barrier
- emergency medical
- trauma patients