Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis.
Ishaque HameedSyeda Ayesha ShahAshnah AijazHasan MushahidSyed Husain FarhanMuhammad DadaAdam Bilal KhanReeha AmjadFawad AlviMustafa MurtazaZaid ZuberiMohammad HamzaPublished in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2024)
This meta-analysis demonstrated that the use of low/moderate-intensity statin combination therapy significantly reduced LDL-C levels compared with high-intensity statin monotherapy, making it preferable for patients with related risks. However, further trials are encouraged to evaluate potential adverse effects associated with combined therapy.
Keyphrases
- high intensity
- combination therapy
- cardiovascular disease
- systematic review
- resistance training
- low density lipoprotein
- coronary artery disease
- meta analyses
- type diabetes
- cardiovascular events
- human health
- cardiovascular risk factors
- case control
- randomized controlled trial
- stem cells
- risk assessment
- clinical trial
- body composition
- open label
- bone marrow