Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers.

Hyemin JangYoung Kyoung JangHee Jin KimDavid John WerringJin San LeeYeong Sim ChoeSeongbeom ParkJuyeon LeeKo Woon KimYeshin KimSoo Hyun ChoSi Eun KimSeung Joo KimAndreas CharidimouDuk L NaSoo Hyun Cho

Published in: European journal of nuclear medicine and molecular imaging (2019)

Our findings suggest that a significant proportion of patients with probable CAA in a memory clinic are Aβ- on PET. Aβ positivity in CAA patients is associated with a distinct pattern of CSVD biomarker expression, and a worse cognitive trajectory. Aβ positivity has clinical relevance in CAA and might represent either advanced CAA or additional Alzheimer's disease neuropathological changes.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
poor prognosis
primary care
computed tomography
prognostic factors
peritoneal dialysis
pet ct
long non coding rna
blood brain barrier
patient reported outcomes
cerebral blood flow