Cognitive performance and brain structural connectome alterations in major depressive disorder.
Marius GruberMarco MauritzSusanne MeinertDominik GrotegerdSiemon C de LangePascal GrumbachJanik GoltermannNils Ralf WinterLena WaltemateHannah LemkeKatharina ThielAlexandra WinterFabian BreuerTiana BorgersVerena EnnekingMelissa KlugKatharina BroschTina MellerJulia-Katharina PfarrKai Gustav RingwaldFrederike SteinNils OpelRonny RedlichTim HahnElisabeth J LeehrJochen BauerIgor NenadićTilo KircherMartijn P van den HeuvelUdo DannlowskiJonathan RepplePublished in: Psychological medicine (2023)
Our study is the first to identify cognition-related structural brain networks in MDD patients, thereby revealing associations between cognitive deficits, depressive symptoms, and reduced structural connectivity. This supports the hypothesis that structural connectome alterations may mediate the association of cognitive deficits and depression severity.
Keyphrases
- major depressive disorder
- resting state
- depressive symptoms
- functional connectivity
- white matter
- bipolar disorder
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- sleep quality
- social support
- multiple sclerosis
- prognostic factors
- cerebral ischemia
- mild cognitive impairment
- blood brain barrier