Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge.

Eva Sanchez-QuantMaria Lucia RichterMaria Colomé-TatchéCelia Pilar Martinez-Jimenez

Published in: Genome biology (2023)

Our results demonstrate that, upon a metabolic challenge such as exposure to drugs or intracellular fat accumulation, hepatocyte subgroups display different and heterogeneous transcriptional responses.

Keyphrases

single cell
liver injury
drug induced
endothelial cells
rna seq
adipose tissue
high throughput
transcription factor
induced pluripotent stem cells
pluripotent stem cells
emergency department
reactive oxygen species
oxidative stress
heat shock
heat shock protein