In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC-MS/MS.

Wenchao SunKhoa Dinh NguyenWilliam L FitchSamuel D BanisterHongxiang TangXiaolan ZhangLewis YuEdgar G EnglemanJayakumar Rajadas

Published in: Rapid communications in mass spectrometry : RCM (2018)

Using both in vitro and in vivo methods, we elucidated the metabolic pathway of ZLN005. Phase I metabolites with hydroxylation and carboxylation, as well as phase II metabolites with glucuronide, sulfate and glutathione conjugation, were identified.

Keyphrases

phase ii
clinical trial
ms ms
open label
phase iii
molecular docking
placebo controlled
double blind
randomized controlled trial
study protocol
molecular dynamics simulations