MARCKSL1 interacted with F-actin to promote esophageal squamous cell carcinoma mobility by modulating the formation of invadopodia.

Yue ZhaoXiufeng XieLusong TianFang LiuYulin SunHaizhen LuXiaohang ZhaoYousheng Mao

Published in: Cancer medicine (2022)

MARCKSL1 promotes cell migration and invasion by interacting with F-actin and cortactin to regulate invadopodia formation and ECM degeneration. High MARCKSL1 expression is positively correlated with poor prognosis in ESCC patients with lymph node metastasis.

Keyphrases

poor prognosis
lymph node metastasis
long non coding rna
squamous cell carcinoma
papillary thyroid
single cell
cell migration
cell therapy
signaling pathway
mesenchymal stem cells
bone marrow