Akt activator SC79 stimulates antibacterial nitric oxide generation in human nasal epithelial cells in vitro.
Robert J LeeNithin D AdappaJames N PalmerPublished in: International forum of allergy & rhinology (2024)
Together, these data suggest multiple immune pathways are stimulated by SC79, with antipathogen effects. This in vitro pilot study suggests that a small-molecule Akt activator may have clinical utility in CRS or respiratory other infection settings, warranting future in vivo studies.
Keyphrases
- small molecule
- nitric oxide
- signaling pathway
- nuclear factor
- cell proliferation
- endothelial cells
- electronic health record
- induced pluripotent stem cells
- current status
- protein protein
- pluripotent stem cells
- nitric oxide synthase
- big data
- hydrogen peroxide
- case control
- toll like receptor
- chronic rhinosinusitis
- inflammatory response
- anti inflammatory