Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.
Daniel Frederick McWilliamsShimin RahmanRichard J E JamesEamonn FergusonPatrick D W KielyAdam YoungDavid A WalshPublished in: BMC rheumatology (2019)
Flares are both common and heterogeneous in people with RA. Furthermore our findings indicate that for some patients there is a discordance between inflammation and pain in flare events. This discrete flare subgroups might reflect different underlying inflammation and pain mechanisms. Treatments addressing different mechanisms might be required to reduce persistent disability after DAS28 and Pain Flares.
Keyphrases
- disease activity
- rheumatoid arthritis
- chronic pain
- systemic lupus erythematosus
- pain management
- neuropathic pain
- ankylosing spondylitis
- rheumatoid arthritis patients
- oxidative stress
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- juvenile idiopathic arthritis
- multiple sclerosis
- prognostic factors
- spinal cord injury
- peritoneal dialysis
- patient reported