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ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4.

Eunhee KoTaejun YoonYoojin LeeJongsun KimYong-Beom Park
Published in: Stem cell research & therapy (2023)
Our findings reveal a detailed cellular outcome and regulatory mechanism of NK cell activity by the ADSC secretome and suggest a therapeutic tool for treating NK-mediated inflammatory and autoimmune diseases using the MSC secretome.
Keyphrases
  • nk cells
  • signaling pathway
  • cell proliferation
  • pi k akt
  • epithelial mesenchymal transition
  • genome wide
  • poor prognosis
  • transcription factor
  • single cell
  • dna methylation
  • endoplasmic reticulum stress