Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59.
Wioleta Milena ZelekLewis M WatkinsOwain W HowellRhian EvansSam LovelessNeil P RobertsonMarijke BeenesLoek WillemsRicardo BrandwijkB Paul MorganPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)
CSF levels of sCD59 are not a biomarker of demyelinating diseases. High levels of sCD59 in CSF relative to plasma suggest an intrathecal source; CD59 expression in brain parenchyma was low, but expression was strong on choroid plexus (CP) epithelium, immediately adjacent the CSF, suggesting that this is the likely source.