Lost in translation: The 3'-UTR of IGF1R as an ancient long noncoding RNA.
Avantika MainieriDavid HaigPublished in: Evolution, medicine, and public health (2018)
The conserved structures we identify in the IGF1R 3'-UTR are strong candidates for regulating cell proliferation during development and carcinogenesis. These conserved structures are now targeted by multiple imprinted microRNAs. These observations emphasize the central importance of IGF signaling pathways in the mediation of intragenomic conflicts over embryonic growth and identify possible targets for therapeutic interventions in cancer.
Keyphrases
- pi k akt
- long noncoding rna
- cell proliferation
- signaling pathway
- binding protein
- transcription factor
- growth hormone
- high resolution
- papillary thyroid
- physical activity
- squamous cell
- social support
- cancer therapy
- squamous cell carcinoma
- epithelial mesenchymal transition
- induced apoptosis
- mass spectrometry
- childhood cancer
- lymph node metastasis
- solid phase extraction