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Lost in translation: The 3'-UTR of IGF1R as an ancient long noncoding RNA.

Avantika MainieriDavid Haig
Published in: Evolution, medicine, and public health (2018)
The conserved structures we identify in the IGF1R 3'-UTR are strong candidates for regulating cell proliferation during development and carcinogenesis. These conserved structures are now targeted by multiple imprinted microRNAs. These observations emphasize the central importance of IGF signaling pathways in the mediation of intragenomic conflicts over embryonic growth and identify possible targets for therapeutic interventions in cancer.
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