Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis.

Julien GuiotI StrumanV ChavezM HenketM HerzogK ScoubeauN HardatB BondueJ L CorhayC MoermansR Louis

Published in: Clinical epigenetics (2017)

Our observations showed that cfnucleosomes (bound HMGB1, mH2A1.1, 5mC, H3K9Ac, and H3K27Ac) might have potential as biomarkers for diagnosis and treatment response. These results deserve further validation in longitudinal cohorts.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
dna methylation
gene expression
cross sectional
human health
climate change
systemic sclerosis