Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.
Derek B ArcherKurt G SchillingNiranjana ShashikumarVaruna JasodanandElizabeth E MooreKimberly R PechmanMurat BilgelLori L Beason-HeldYang AnAndrea T ShaferLuigi FerrucciShannon L RisacherKatherine A GiffordBennett A LandmanAngela L JeffersonAndrew J SaykinSusan M ResnickTimothy J Hohmannull nullPublished in: bioRxiv : the preprint server for biology (2023)
Longitudinal data was free-water corrected and harmonizedGlobal effects of white matter decline were seen in normal and abnormal agingThe free-water metric was most vulnerable to abnormal agingCingulum free-water was the most vulnerable to abnormal aging.