Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding.

Manisha RayYasuyuki KiharaDarryl J BornhopJerold Chun

Published in: Lipids in health and disease (2021)

Antibody binding specificity and sensitivity, particularly involving lipid ligands, can be assessed in solution and without labels using FSA-CIR. These findings could affect interpretations of both current and past basic and clinical studies employing 504B3 and related anti-LPA antibodies.

Keyphrases

dna binding
genome wide
social media
binding protein
high speed
gene expression
fatty acid
dna methylation