NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome.
Luiza HandschuhPawel WojciechowskiMaciej KazmierczakMalgorzata Marcinkowska-SwojakMagdalena LuczakKrzysztof LewandowskiMieczyslaw KomarnickiJacek BlazewiczMarek FiglerowiczPiotr KozlowskiPublished in: Journal of translational medicine (2018)
The levels of the studied NPM1 transcripts were different but highly correlated with each other. Their upregulation in AML and ALL, decrease after therapy and association with patient outcome suggests the involvement of elevated NPM1 expression in the acute leukemia pathogenesis.
Keyphrases
- acute myeloid leukemia
- poor prognosis
- allogeneic hematopoietic stem cell transplantation
- case report
- long non coding rna
- liver failure
- binding protein
- cell proliferation
- bone marrow
- drug induced
- respiratory failure
- stem cells
- immune response
- dendritic cells
- intensive care unit
- aortic dissection
- mesenchymal stem cells
- replacement therapy