Effects of Alirocumab on Triglyceride Metabolism: A Fat-Tolerance Test and Nuclear Magnetic Resonance Spectroscopy Study.

Thomas MetznerDeborah R LeitnerKarin MellitzerAndrea BeckHarald SourijTatjana StojakovicGernot ReishoferWinfried MärzUlf LandmesserHubert Scharnagl Hermann ToplakGünther Silbernagel

Published in: Biomedicines (2022)

Significant effects of alirocumab on triglyceride metabolism were not detectable in the ALIROCKS trial. The total circulating PCSK9 concentration might be a useful biomarker to differentiate non-adherence from non-response to PCSK9 antibodies.

Keyphrases

low density lipoprotein
adipose tissue
clinical trial
study protocol
phase iii
randomized controlled trial
type diabetes
metabolic syndrome