Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.

Maria Chiara De SantisLuca Gozzelino Jean Piero MargariaAndrea CostamagnaEdoardo RattoFederico GulluniEnza Di GregorioErica MinaNicla LoritoMarina BacciRossano LattanzioGianluca Sala Paola CappelloFrancesco NovelliElisa GiovannettiCaterina VicentiniSilvia AndreaniPietro DelfinoVincenzo Corbo Aldo ScarpaPaolo Ettore PorporatoAndrea MorandiEmilio HirschMiriam Martini

Published in: Gut (2022)

Loss of PI3K-C2γ prevents mTOR inactivation and triggers tumour vulnerability to RAD001 (mTOR inhibitor) and BPTES/CB-839 (glutaminase inhibitors). Therefore, these results might open the way to personalised treatments in PDAC with PI3K-C2γ loss.

Keyphrases

cell proliferation
dna damage
minimally invasive
cancer therapy
dna repair
mouse model
fatty acid
drug delivery