HMGB1: A pleiotropic activity.
Laura ColavitaRiccardo CastagnoliAnnamaria SalpietroCaterina CuppariPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)
High-mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage-associated molecular pattern (DAMP) molecules, also called alarmins. For this, HMGB1 has been studied in several acute and chronic inflammatory diseases as an early biomarker of inflammation. An increased concentration of HMGB1 has been detected in serum, as the expression of systemic inflammation, and in specific samples (such as stool, synovial fluid, nasal lavage fluid, sputum, and cerebrospinal fluid), as the expression of local production, in several infectious and/or inflammatory diseases. These data are particularly important because they open new futuristic possibilities for target therapies, potentially also for the COVID-19 treatment.
Keyphrases
- oxidative stress
- poor prognosis
- binding protein
- cerebrospinal fluid
- coronavirus disease
- sars cov
- transcription factor
- liver failure
- cystic fibrosis
- electronic health record
- big data
- minimally invasive
- pulmonary tuberculosis
- small molecule
- hepatitis b virus
- respiratory failure
- deep learning
- mechanical ventilation
- acute respiratory distress syndrome
- respiratory syndrome coronavirus
- protein protein