Testosterone supplementation increases red blood cell susceptibility to oxidative stress, decreases membrane deformability, and decreases survival after cold storage and transfusion.
Johnson Q TranRachael P JackmanMarcus O MuenchKelsey HazeghScott-Wesley BeanKimberly A ThomasFang FangGrier PageKim O'ConnorNareg H RoubinianBradley D AnawaltTamir KaniasPublished in: Transfusion (2024)
TT is associated with altered RBC characteristics and transfusion effectiveness. These results suggest that clinical utilization of TT RBCs may be less effective in recipients who benefit from longer RBC survival, such as chronically transfused patients.
Keyphrases
- red blood cell
- oxidative stress
- end stage renal disease
- cardiac surgery
- ejection fraction
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- systematic review
- prognostic factors
- peritoneal dialysis
- ischemia reperfusion injury
- patient reported outcomes
- replacement therapy
- diabetic rats
- smoking cessation