Circulating Tumor DNA in Colorectal Cancer Liver Metastasis: Analysis of Patients Receiving Liver Resection and Transplant.
Chase J WehrleRoma RajNihal AykunDanny OrabiKathryn StackhouseJenny H ChangBassam EstfanSuneel D KamathSmitha KrishnamurthiR Matthew WalshChoon-Hyuck David KwonFederico AucejoPublished in: JCO clinical cancer informatics (2023)
Routine ctDNA screening in patients with CCLM is logistically feasible. Liver resection and/or transplant may be associated with clearance of detectable ctDNA and a reduction in TMB or genomic heterogeneity. Persistence of ctDNA alterations postresection appears predictive of disease recurrence. Further studies are necessary to confirm these findings, and longitudinal ctDNA testing is needed to monitor changing tumor biology.