Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial.
Anna Tresserra-RimbauSara Castro-BaqueroNerea Becerra-TomásNancy Elvira Babio SánchezMaría Ángeles MartínezDolores CorellaMontserrat FitóDora RomagueraJesús VioqueÁngel María Alonso-GómezJulia WärnbergJosé Alfredo Martínez HernándezJ LLuís Serra-MajemRamon EstruchFrancisco J TinahonesJosé LapetraXavier PintoJosep Antonio TurJose Lopez-MirandaNaomi Cano-IbáñezMiguel Delgado-RodríguezPilar Matía-MartínLidia Daimiel RuizVicente Martín SánchezJosep VidalClotilde VázquezEmilio RosFrancisco Javier BasterraMaría Fernández de la PuenteEva M AsensioOlga CastanerMaría Vanessa Bullón VelaLucas Tojal-SierraEnrique Gómez-GraciaEugenio Cases-PérezJadwiga KoniecznaAntonio García-RíosTamara Casañas-QuintanaMaria Rosa Bernal-LopezJosé Manuel Santos-LozanoVirginia Esteve-LuqueCristina BouzasZenaida Vazquez-RuízAntoni Palau-GalindoRocío BarragánMercè López GrauCristina RazquinLeire Goicolea-GüemezEstefania Toledo-AtuchaManel Vila VergazRosa Maria Lamuela-RaventósJordi Salas SalvadóPublished in: Antioxidants (Basel, Switzerland) (2022)
Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
Keyphrases
- metabolic syndrome
- weight loss
- weight gain
- blood glucose
- type diabetes
- physical activity
- insulin resistance
- risk factors
- healthcare
- cardiovascular disease
- glycemic control
- randomized controlled trial
- pregnant women
- polycystic ovary syndrome
- high resolution
- blood pressure
- phase iii
- uric acid
- risk assessment
- skeletal muscle