Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation.

Anja MaagPriyanka SharmaTim J SchuijtWil F KopatzDaniëlle KruijswijkJ Arnoud MarquartTom van der PollTilman M HackengGerry A F NicolaesJoost C M MeijersMettine H A BosCornelis van 't Veer

Published in: Journal of thrombosis and haemostasis : JTH (2021)

The structure-function properties of TIX-5 are in perfect agreement with a protein that inhibits the FXa-mediated activation on a phospholipid surface. The present elucidation of the mechanism of action of TIX-5 will aid in deciphering the processes involved in the initiation phase of blood coagulation.

Keyphrases

venous thromboembolism
atrial fibrillation
fatty acid
protein protein
small molecule