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DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function.

Ildiko MadurkaAlexander VishnevskyJoan B SorianoStephanus J GansDanilo Joel Salazar OreAdrian RendonCharlotte S UlrikSushma BhatnagarSrikanth KrishnamurthyKirsten Mc HarryTobias WelteAlberto A FernandezBeata MehesKarin MeiserEwa GatlikUlrike SommerGuido JungeEderlon Rezendenull null
Published in: Infection (2022)
ClinicalTrials.gov, NCT04382053.
Keyphrases
  • clinical trial
  • open label
  • double blind
  • phase ii
  • study protocol
  • phase iii
  • placebo controlled
  • nlrp inflammasome
  • randomized controlled trial
  • respiratory failure
  • intensive care unit