Disulfiram Is Effective against Drug-Resistant Mycobacterium abscessus in a Zebrafish Embryo Infection Model.
Carlynn G WintersRam M BasnetPaige E FaasuamalieShamira J ShallomAdrian M ZelaznyShashank GuptaKenneth N OlivierPublished in: Antimicrobial agents and chemotherapy (2022)
Mycobacterium abscessus is an emerging nontuberculous mycobacterium (NTM) pathogen infecting susceptible people with cystic fibrosis (CF) and non-CF bronchiectasis. Here, we demonstrated the activity of an FDA-approved drug, disulfiram, against drug-susceptible and drug-resistant M. abscessus strains utilizing in vitro and intracellular macrophage assays and a zebrafish embryo infection model. These data demonstrate effective antimicrobial activity of disulfiram against M. abscessus infection in vivo and strongly support further study of disulfiram in human NTM infections.
Keyphrases
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- cystic fibrosis
- mycobacterium tuberculosis
- endothelial cells
- escherichia coli
- emergency department
- pregnancy outcomes
- high throughput
- induced pluripotent stem cells
- adverse drug
- machine learning
- artificial intelligence
- pluripotent stem cells
- drug administration