Phenylethanoid glycosides extract from Cistanche deserticola ameliorates atherosclerosis in apolipoprotein E-deficient mice and regulates intestinal PPARγ-LXRα-ABCA1 pathway.

Xiubin JiaBoyan LiuJunli XueYunchao LiuJingjun ZhangShucun QinYing Zhang

Published in: The Journal of pharmacy and pharmacology (2023)

Our results demonstrate the beneficial effects of C. deserticola on atherosclerotic plaques and lipid homeostasis, and it is, at least partially, by activating PPARγ-LXRα-ABCA1 pathway in small intestine.

Keyphrases

fatty acid
insulin resistance
cardiovascular disease
oxidative stress
signaling pathway
mouse model
type diabetes
adipose tissue
skeletal muscle