Dynamics of Methylation of CpG Sites Associated With Systemic Lupus Erythematosus Subtypes in a Longitudinal Cohort.
Cristina M LanataJoanne NitithamKimberly E TaylorOlivia SolomonSharon A ChungAshira BlazerLaura TrupinPatricia P KatzMaria Dall'EraRebecca GraingerMarina SirotaLisa F BarcellosLindsey A CriswellPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
In this longitudinal SLE cohort, we identified a subset of SLE subtype-associated CpGs that remained stable over time and may be useful as biomarkers of disease subtypes. Another subset of SLE subtype-associated CpGs changed at a higher proportion compared to the genome-wide methylome. Additional studies are needed to understand the etiology and impact of these changes on methylation of SLE-associated CpGs.