Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans.
Marienela Y HerediaDeepika GunasekaranMélanie A C IkehClarissa J NobileJason M RauceoPublished in: Current genetics (2020)
The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidiasis. Signaling pathways are critical in coordinating the adaptive response to cell wall damage (CWD). C. albicans executes a robust transcriptional program following caspofungin-induced CWD. A comprehensive analysis of signaling pathways at the transcriptional level facilitates the identification of prospective genes for functional characterization and propels the development of novel antifungal interventions. This review article focuses on the molecular functions and signaling crosstalk of the C. albicans transcription factors Sko1, Rlm1, and Cas5 in caspofungin-induced CWD signaling.
Keyphrases
- candida albicans
- cell wall
- biofilm formation
- high glucose
- transcription factor
- diabetic rats
- endothelial cells
- signaling pathway
- oxidative stress
- drug induced
- gene expression
- emergency department
- crispr cas
- escherichia coli
- quality improvement
- pi k akt
- epithelial mesenchymal transition
- dna methylation
- cell proliferation
- single molecule
- pseudomonas aeruginosa
- genome editing
- adverse drug
- induced pluripotent stem cells
- induced apoptosis