Neurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia.
Christoph KesslerLina M Serna-HiguitaTim W RattayWalter MaetzlerIsabel WursterStefanie HayerCarlo WilkeHolger HengelJennifer ReichbauerMarcel ArmbrusterLudger SchölsPeter MartusRebecca SchülePublished in: Annals of clinical and translational neurology (2021)
CSF NfL is a reliable cross-sectional biomarker in hereditary spastic paraplegia. Sex is a relevant factor to consider, as male patients have remarkably higher CSF NfL levels. While levels also increase with age, the gap between patients and controls is narrowing in older subjects. This indicates distinct temporal dynamics of CSF NfL in patients with hereditary spastic paraplegia, with a rise around phenotypic conversion and comparatively static levels afterward.